Eosinophil lysis and plasma extravasation

Eosinophil lysis and plasma extravasation.

I read with interest two recent Editorials, one by ALBERA and GHIO [1] on eosinophil activation (in eosinophilic pneumonia) and the other by KUBES [2], which discusses plasma extravasation (in animal tissues). While these editorials no doubt deal extremely well with topical notions in these fields, there are a few additional aspects that might be of general interest. With regard to eosinophil a...

Glucocorticoids inhibit neurogenic plasma extravasation and prevent virus-potentiated extravasation in the rat trachea.

Capsaicin increases the permeability of blood vessels in the rat tracheal mucosa through a mechanism involving the release of tachykinins from sensory nerves. This capsaicin-induced increase in vascular permeability is potentiated by viral infections of the respiratory tract. The present study was done to determine whether this "neurogenic plasma extravasation" can be inhibited by glucocorticoi...

Airway microvascular extravasation and luminal entry of plasma.

Extravasation of plasma from postcapillary venules is a specific in vivo response to inflammatory insults. In the nasal and bronchial airways, extravasated plasma has a widespread distribution in the lamina propria, between the epithelial cells and in the airway lumen. This feature, in combination with the fact that the process involves extravasation of bulk plasma, with all peptides and protei...

Human eosinophil peroxidase induces surface alteration, killing, and lysis of Mycobacterium tuberculosis.

The antimycobacterial role of eosinophil peroxidase (EPO), one of the most abundant granule proteins in human eosinophils, was investigated. Our data indicate that purified EPO shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv. On a molar basis, this activity was similar to that exhibited by neutrophil myeloperoxidase (MPO) and was both dose and time dependent. In c...

"Ultimate activation" of eosinophils in vivo: lysis and release of clusters of free eosinophil granules (Cfegs).